SCHEMBL29957097

SCHEMBL29957097

O=Cc1c[nH]c2cc(F)cc(F)c12

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.44
CYP2A6 P11509 3/20 0.42
IMPDH2 P12268 1/20 0.39
TDO2 P48775 1/20 0.37
PIM1 P11309 1/20 0.36
PIM3 Q86V86 1/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
PLG P00747 1/20 0.34
PLAU P00749 1/20 0.34
CCNT1 O60563 1/20 0.33
CDK9 P50750 1/20 0.33
HASPIN Q8TF76 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17958314 1.00 ERN1 (0.44) ERN1CYP2A6IMPDH2TDO2PIM1
SCHEMBL29953083 0.82 CYP2A6 (0.44) ERN1CYP2A6IMPDH2TDO2ALDH1A1
SCHEMBL29954571 0.82 CYP2A6 (0.40) ERN1CYP2A6IMPDH2TDO2ALDH1A1
SCHEMBL29951496 0.82 CYP2A6 (0.56) ERN1CYP2A6IMPDH2TDO2PIM1
SCHEMBL29957909 0.82 CYP2A6 (0.40) ERN1CYP2A6IMPDH2ALDH1A1CYP1A2
SCHEMBL29953426 0.82 HTR1A (0.47) ERN1CYP2A6IMPDH2TDO2ALDH1A1
SCHEMBL29951141 0.82 CYP2A6 (0.51) ERN1CYP2A6IMPDH2PIM1PIM3
SCHEMBL12107006 0.78 CYP2A6 (0.37) CYP2A6IMPDH2ALDH1A1CYP1A2CYP2C19
SCHEMBL12109753 0.78 CYP2A6 (0.37) CYP2A6IMPDH2PIM1PIM3ALDH1A1
SCHEMBL29954599 0.78 ALDH1A1 (0.44) ERN1CYP2A6IMPDH2ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4313985-A2 HETEROCYCLIC COMPOUNDS AND THEIR USE Equinorm Ltd (FI) 2024-02-07 EP disclosed
CN-117412975-A Heterocyclic compounds and their use 伊科诺姆有限公司 2024-01-16 CN disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
WO-2022207979-A2 NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE EQUINORM LTD (FI) 2022-10-06 WO disclosed