Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 16/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29958329 | 0.84 | SMN1; SMN2 (0.42) | METTL3KLKB1 | |
| SCHEMBL29957846 | 0.81 | METTL3 (0.41) | METTL3KLKB1 | |
| SCHEMBL27033446 | 0.81 | METTL3 (0.41) | METTL3KLKB1 | |
| SCHEMBL24738257 | 0.81 | METTL3 (0.39) | METTL3KLKB1 | |
| SCHEMBL30711722 | 0.79 | KDM4E (0.41) | METTL3KLKB1 | |
| SCHEMBL29880148 | 0.78 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL24739315 | 0.78 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL30997765 | 0.78 | METTL3 (0.43) | METTL3KLKB1 | |
| SCHEMBL30997865 | 0.76 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL29303099 | 0.76 | KLKB1 (0.39) | METTL3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |