Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24729570 | 0.84 | SMN1; SMN2 (0.41) | SMN1; SMN2KDM4ENPC1RAB9AGRM5 | |
| SCHEMBL24729569 | 0.84 | METTL3 (0.39) | SMN1; SMN2KDM4ENPC1RAB9AGRM5 | |
| SCHEMBL29957835 | 0.84 | METTL3 (0.38) | METTL3KLKB1 | |
| SCHEMBL24729668 | 0.82 | METTL3 (0.39) | SMN1; SMN2KDM4ENPC1RAB9AMETTL3 | |
| SCHEMBL29303099 | 0.81 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL30997865 | 0.81 | KLKB1 (0.39) | METTL3KLKB1 | |
| SCHEMBL24729661 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL29141754 | 0.79 | METTL3 (0.41) | KDM4EMETTL3KLKB1 | |
| SCHEMBL24738256 | 0.78 | KLKB1 (0.38) | SMN1; SMN2KDM4ENPC1RAB9AGRM5 | |
| SCHEMBL30711687 | 0.78 | KLKB1 (0.39) | METTL3KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |