SCHEMBL29957979

SCHEMBL29957979

O=Cc1c[nH]c2cc(-c3cccnc3)ccc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 1/20 0.57
CDK9 P50750 1/20 0.57
HASPIN Q8TF76 1/20 0.57
ERN1 O75460 3/20 0.56
QPCT Q16769 1/20 0.52
QPCTL Q9NXS2 1/20 0.52
CYP2A6 P11509 2/20 0.50
TDO2 P48775 4/20 0.49
NR4A2 P43354 1/20 0.48
IDO1 P14902 1/20 0.48
IMPDH2 P12268 1/20 0.47
TTK P33981 1/20 0.47
FGFR1 P11362 1/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
KMT2A Q03164 1/20 0.47
CHEK1 O14757 1/20 0.46
PIM1 P11309 1/20 0.45
PIM3 Q86V86 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29953157 0.89 NR4A2 (0.57) CCNT1CDK9HASPINERN1QPCT
SCHEMBL26700908 0.82 CCNT1 (0.58) CCNT1CDK9HASPINERN1CYP2A6
SCHEMBL2535062 0.82 CYP2A6 (0.61) CCNT1CDK9HASPINCYP2A6NR4A2
SCHEMBL15331451 0.77 CYP2A6 (0.53) CCNT1CDK9HASPINCYP2A6TDO2
SCHEMBL857279 0.77 KMT2A (0.60) CCNT1CDK9HASPINERN1KMT2A
SCHEMBL28068053 0.76 CCNT1 (0.49) CCNT1CDK9HASPINCYP2A6TDO2
SCHEMBL28107195 0.75 CCNT1 (0.57) CCNT1CDK9HASPINQPCTQPCTL
SCHEMBL7844961 0.75 CYP2A6 (0.57) CCNT1CDK9HASPINCYP2A6TDO2
SCHEMBL29664462 0.74 CCNT1 (0.62) CCNT1CDK9HASPINCYP2A6IMPDH2
SCHEMBL2268299 0.74 CCNT1 (0.62) CCNT1CDK9HASPINCYP2A6IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed