Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27033341 | 1.00 | SIRT1 (0.52) | SIRT1MAPTL3MBTL1DRD2DRD3 | |
| SCHEMBL29174303 | 0.94 | SIRT1 (0.48) | SIRT1MAPTL3MBTL1DRD2DRD3 | |
| SCHEMBL29958290 | 0.85 | NOTUM (0.43) | MAPTDRD2DRD3SRD5A1HTR2A | |
| SCHEMBL27033717 | 0.85 | NOTUM (0.43) | MAPTDRD2DRD3SRD5A1HTR2A | |
| SCHEMBL367380 | 0.81 | KDM1A (0.46) | SIRT1DRD2DRD3HDAC8 | |
| SCHEMBL27033455 | 0.80 | MAPT (0.43) | MAPTL3MBTL1HDAC8SMN1; SMN2 | |
| SCHEMBL29958397 | 0.80 | MAPT (0.43) | MAPTL3MBTL1HDAC8SMN1; SMN2 | |
| SCHEMBL29174302 | 0.78 | SIRT1 (0.36) | SIRT1MAPTL3MBTL1DRD2DRD3 | |
| SCHEMBL346421 | 0.78 | PLAU (0.52) | — | |
| SCHEMBL30711622 | 0.78 | PLAU (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308228-A1 | PLASMA KALLIKREIN INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| CN-117396474-A | Plasma kallikrein inhibitors | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022197756-A1 | PLASMA KALLIKREIN INHIBITORS | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |