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SCHEMBL29959019

SCHEMBL29959019

CC(C)(C)OC(=O)N1C[C@@H](F)C(=O)C(C)(C)C1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 2/20 0.43
▸ DDB1 Q16531 1/20 0.41
▸ CRBN Q96SW2 1/20 0.41
▸ RORC P51449 11/20 0.41
▸ KDM4E B2RXH2 1/20 0.38
▸ USP2 O75604 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23579409 1.00 NR1H2 (0.43) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL15740984 1.00 NR1H2 (0.43) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL23579468 0.87 DDB1 (0.43) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL12488892 0.82 RORC (0.44) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL19555254 0.82 RORC (0.44) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL15742012 0.82 DDB1 (0.39) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL5133428 0.81 RORC (0.43) NR1H2DDB1CRBNRORCUSP2
SCHEMBL12364068 0.81 NR1H2 (0.40) NR1H2DDB1CRBNRORCUSP2
SCHEMBL26007583 0.80 DDB1 (0.38) NR1H2DDB1CRBNRORCKDM4E
SCHEMBL15743105 0.80 DDB1 (0.38) NR1H2DDB1CRBNRORCKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115135642-B Inhibitors of EGFR mutant forms 缆图药品公司 2025-03-04 — — CN disclosed
CN-115135642-A Inhibitors of mutant forms of EGFR 缆图药品公司 2022-09-30 — — CN disclosed