Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.36 |
| ▸ | LATS1 | O95835 | 4/20 | 0.35 |
| ▸ | LATS2 | Q9NRM7 | 4/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31345172 | 1.00 | LMNA (0.40) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12045006 | 1.00 | LMNA (0.40) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12045002 | 0.86 | LMNA (0.39) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2607319 | 0.80 | LMNA (0.53) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27317248 | 0.80 | HTT (0.41) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2607435 | 0.79 | ADRA2A (0.44) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29875062 | 0.79 | ADRA2A (0.44) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12789725 | 0.77 | CYP1A2 (0.40) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20990532 | 0.77 | HASPIN (0.38) | LMNAKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20315030 | 0.76 | RPS6KA3 (0.42) | LMNAKDM4ECYP1A2MAPKAPK2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023071998-A1 | NOVEL PYRIDO OR TRIAZINE-SUBSTITUTED PYRIDO HETEROCYCLIC COMPOUND | 杭州德睿智药科技有限公司 | 2023-05-04 | — | — | WO | disclosed |
| CN-115135642-A | Inhibitors of mutant forms of EGFR | 缆图药品公司 | 2022-09-30 | — | — | CN | disclosed |