Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.59 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409961 | 1.00 | TGFBR1 (0.59) | TGFBR1MAPK14ASAH1POLBTHRB | |
| SCHEMBL23409664 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14THRBTP53AURKA | |
| SCHEMBL29959820 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14THRBTP53AURKA | |
| SCHEMBL28822071 | 0.90 | TGFBR1 (0.69) | TGFBR1MAPK14BRAFAURKAAURKB | |
| SCHEMBL23409906 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14LMNA | |
| SCHEMBL23409924 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14THRB | |
| SCHEMBL29959696 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14LMNA | |
| SCHEMBL29959785 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14THRB | |
| SCHEMBL28822096 | 0.88 | TGFBR1 (0.56) | TGFBR1MAPK14THRBAURKAAURKB | |
| SCHEMBL23409662 | 0.87 | TGFBR1 (0.56) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | claimed |
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |