Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | PANK1 | Q8TE04 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23409906 | 1.00 | TGFBR1 (0.59) | TGFBR1MAPK14CNR1ENPP2KMT2A | |
| SCHEMBL28822077 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14CNR1ENPP2LMNA | |
| SCHEMBL28822071 | 0.90 | TGFBR1 (0.69) | TGFBR1MAPK14CNR1LMNA | |
| SCHEMBL29959467 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14LMNA | |
| SCHEMBL23409924 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14CNR1KMT2A | |
| SCHEMBL23409961 | 0.90 | TGFBR1 (0.59) | TGFBR1MAPK14LMNA | |
| SCHEMBL29959785 | 0.90 | TGFBR1 (0.61) | TGFBR1MAPK14CNR1KMT2A | |
| SCHEMBL28822069 | 0.88 | TGFBR1 (0.56) | TGFBR1MAPK14LMNA | |
| SCHEMBL23409662 | 0.87 | TGFBR1 (0.56) | TGFBR1MAPK14 | |
| SCHEMBL29959975 | 0.87 | TGFBR1 (0.56) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114787145-B | Benzamide derivatives as transforming growth factor-beta receptor I/ALK5 inhibitors | 阿戈麦布西班牙股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-4065572-A1 | BENZYLAMIDE DERIVATIVES AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA RECEPTOR I/ALK5 | Origo Biopharma, S.L. (ES) | 2022-10-05 | — | — | EP | disclosed |