Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.55 |
| ▸ | MIF | P14174 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2996022 | 1.00 | HTR1D (0.55) | HTR1DTRPM8MIFHTR1BHTR1A | |
| SCHEMBL2993313 | 0.86 | KMT2A (0.55) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL2993315 | 0.86 | KMT2A (0.55) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3001041 | 0.86 | KMT2A (0.54) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL3000908 | 0.85 | HTR1D (0.54) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL3000905 | 0.85 | HTR1D (0.54) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL3000105 | 0.83 | HTR1D (0.53) | HTR1DMIFHTR1BHTR1AKDM4E | |
| SCHEMBL3000108 | 0.83 | HTR1D (0.53) | HTR1DMIFHTR1BHTR1AKDM4E | |
| SCHEMBL13209506 | 0.82 | HTR1D (0.57) | HTR1DHTR1BHTR1AKDM4EALDH1A1 | |
| SCHEMBL10548535 | 0.76 | TRPM8 (0.54) | TRPM8MIFHTR1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786156-B2 | Synthesis methods and intermediates for the manufacture of Rizatriptan | RATIOPHARM GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-7786156-B2 | Synthesis methods and intermediates for the manufacture of Rizatriptan | RATIOPHARM GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| EP-1751104-B1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2010-03-24 | — | — | EP | disclosed |
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | RATIOPHARM GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | RATIOPHARM GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| EP-1751104-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | ratiopharm GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005075422-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | HTR7, HRH4, CA7 | HTR1D 48/4885TRPM8 380/4885MIF 1987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.