Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28510099 | 1.00 | GPR119 (0.50) | GPR119CHRNB2CHRNA4SLC2A1CHEK2 | |
| SCHEMBL7522800 | 0.94 | IDO1 (0.50) | GPR119CHRNB2CHRNA4SLC2A1CHEK2 | |
| SCHEMBL19418738 | 0.86 | GPR119 (0.52) | GPR119SLC2A1CHEK2HDAC1FAAH | |
| SCHEMBL19418740 | 0.86 | GPR119 (0.52) | GPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL29913117 | 0.85 | GPR119 (0.49) | GPR119SLC2A1CHEK2 | |
| SCHEMBL27158797 | 0.85 | GPR119 (0.49) | GPR119SLC2A1CHEK2 | |
| SCHEMBL19420093 | 0.84 | GPR119 (0.52) | GPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL29576543 | 0.83 | SLC2A1 (0.55) | GPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL864389 | 0.83 | SLC2A1 (0.55) | GPR119SLC2A1CHEK2HDAC1 | |
| SCHEMBL4264039 | 0.83 | GPR119 (0.51) | GPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047928-B | Isonicotinamide AChE-GSK3 double inhibitor and preparation method and application thereof | 中国药科大学 | 2022-09-23 | — | — | CN | disclosed |