Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 13/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964963 | 0.81 | KDM4E (0.70) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL29964762 | 0.81 | CCR5 (0.53) | CCR5KDM4ETDP1 | |
| SCHEMBL29964333 | 0.72 | CCR5 (0.52) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL29965021 | 0.71 | KDM4E (0.65) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL29964086 | 0.68 | KDM4E (0.42) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL27159965 | 0.68 | KDM4E (0.42) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL29964740 | 0.68 | CCR5 (0.42) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL5699910 | 0.68 | CCR5 (1.00) | CCR5 | |
| SCHEMBL3157458 | 0.68 | CCR5 (0.58) | CCR5KDM4ETDP1ALDH1A1 | |
| SCHEMBL1428200 | 0.67 | KDM4E (0.53) | CCR5KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | CCR5 3103/4885KDM4E 1986/4885TDP1 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.