Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27159779 | 1.00 | PDE3B (0.40) | PDE3BPDE3AMEN1KMT2APARP1 | |
| SCHEMBL27159724 | 0.76 | LMNA (0.44) | PDE3BPDE3AKMT2APARP1LMNA | |
| SCHEMBL27159705 | 0.75 | PDE3B (0.34) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL30816234 | 0.75 | PDE3B (0.34) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL29914858 | 0.72 | MEN1 (0.47) | PDE3BPDE3AMEN1KMT2APARP1 | |
| SCHEMBL27159981 | 0.71 | ROCK1 (0.41) | PARP1ENPP2CA2LPLLIPG | |
| SCHEMBL29914860 | 0.71 | ROCK1 (0.41) | PARP1ENPP2CA2LPLLIPG | |
| SCHEMBL27157700 | 0.69 | PARP1 (0.54) | PARP1GAAKDM4ELMNASMN1; SMN2 | |
| SCHEMBL20227598 | 0.68 | PARP1 (0.58) | MEN1KMT2APARP1KDM4ELMNA | |
| SCHEMBL2630518 | 0.66 | CA1 (0.44) | PARP1TTRENPP2CA2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |