Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 3/20 | 0.47 |
| ▸ | TNKS | O95271 | 2/20 | 0.47 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21387271 | 0.78 | PARP1 (0.50) | MEN1KMT2APARP1KDM4EALDH1A1 | |
| SCHEMBL27159724 | 0.76 | LMNA (0.44) | KMT2APARP1LMNACYP1A2HSD17B10 | |
| SCHEMBL26018099 | 0.75 | SERPINE1 (0.47) | MEN1KMT2APARP1KDM4EALDH1A1 | |
| SCHEMBL2673475 | 0.75 | PARP1 (0.47) | MEN1KMT2APARP1KDM4EALDH1A1 | |
| SCHEMBL29914921 | 0.75 | PARP1 (0.47) | MEN1KMT2APARP1KDM4EALDH1A1 | |
| SCHEMBL917825 | 0.75 | SERPINE1 (0.58) | MEN1KMT2APARP1KDM4EALDH1A1 | |
| SCHEMBL5017370 | 0.74 | SERPINE1 (0.55) | PARP1TNKS2TNKSSERPINE1MAPT | |
| SCHEMBL29914878 | 0.74 | PARP1 (0.47) | MEN1KMT2APARP1 | |
| SCHEMBL3228523 | 0.74 | AHR (0.61) | MEN1KMT2AKDM4EALDH1A1TNKS2 | |
| SCHEMBL27159779 | 0.72 | PDE3B (0.40) | MEN1KMT2APARP1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022226665-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |