Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 16/20 | 0.63 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029334 | 1.00 | TYMS (0.63) | TYMSQTRT1DYRK1AGAAMAPT | |
| SCHEMBL6653029 | 0.80 | TYMS (0.81) | TYMS | |
| SCHEMBL21089737 | 0.79 | NPC1 (0.44) | TYMSGAAMAPTNPSR1RXFP1 | |
| SCHEMBL29440611 | 0.79 | TYMS (0.63) | TYMSGAAMAPTNPSR1 | |
| SCHEMBL13102494 | 0.79 | TYMS (0.63) | TYMSQTRT1MAPT | |
| SCHEMBL30012731 | 0.79 | NPC1 (0.44) | TYMSGAAMAPTNPSR1RXFP1 | |
| SCHEMBL3226572 | 0.79 | TYMS (0.63) | TYMSGAAMAPTNPSR1 | |
| SCHEMBL6455624 | 0.78 | TYMS (1.00) | TYMS | |
| SCHEMBL25204007 | 0.76 | ALDH1A1 (0.58) | TYMSGAAMAPTNPSR1RXFP1 | |
| SCHEMBL4973391 | 0.76 | KDM4E (0.63) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | TYMS 1583/4885QTRT1 2442/4885DYRK1A 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.