Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 4/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | FPR3 | P25089 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964863 | 1.00 | CHEK2 (0.55) | CHEK2USP30FPR2GPR119CHRNA7 | |
| SCHEMBL3344897 | 0.93 | GPR119 (0.57) | CHEK2USP30FPR2GPR119FPR3 | |
| SCHEMBL22953093 | 0.93 | GPR119 (0.57) | CHEK2USP30FPR2GPR119FPR3 | |
| SCHEMBL24467408 | 0.93 | GPR119 (0.57) | CHEK2USP30FPR2GPR119FPR3 | |
| SCHEMBL29981523 | 0.90 | GPR119 (0.60) | CHEK2USP30FPR2GPR119PDE4B | |
| SCHEMBL23410116 | 0.90 | GPR119 (0.60) | CHEK2USP30FPR2GPR119PDE4B | |
| SCHEMBL4358976 | 0.89 | CHEK2 (0.59) | CHEK2USP30GPR119PDE4BPRMT5 | |
| SCHEMBL19838590 | 0.88 | CHEK2 (0.55) | CHEK2USP30GPR119PDE4BPRMT5 | |
| SCHEMBL19838592 | 0.88 | CHEK2 (0.55) | CHEK2USP30GPR119PDE4BPRMT5 | |
| SCHEMBL3343250 | 0.87 | USP30 (0.52) | CHEK2USP30FPR2GPR119FPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | CHEK2 162/4885USP30 3239/4885FPR2 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.