Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31145931 | 0.80 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28677927 | 0.63 | PDE4B (0.49) | PDE4BCDC7 | |
| SCHEMBL20757040 | 0.62 | GRM5 (0.46) | PDE4B | |
| SCHEMBL26453573 | 0.61 | PARP10 (0.45) | — | |
| SCHEMBL18352015 | 0.61 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL25797393 | 0.61 | PARP1 (0.51) | PDE4BRIPK3 | |
| SCHEMBL23314219 | 0.60 | MAP4K1 (0.38) | — | |
| SCHEMBL17174633 | 0.60 | L3MBTL1 (0.34) | CDC7 | |
| SCHEMBL23487968 | 0.60 | CHEK1 (0.33) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5133297 | 0.60 | PDE4B (0.49) | PDE4BCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |