Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20679600 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2MAP2K1MAPTKMT2AKDM4E | |
| SCHEMBL27398825 | 0.88 | GRM4 (0.58) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL31051186 | 0.88 | GRM4 (0.58) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL22069579 | 0.87 | ALDH1A1 (0.49) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL22069737 | 0.86 | FFAR1 (0.53) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL8327094 | 0.86 | TSHR (0.59) | SMN1; SMN2MAP2K1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL20679550 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL29663501 | 0.86 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL22069644 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL22069584 | 0.85 | MAPT (0.50) | SMN1; SMN2MAPTKMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313988-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117396480-A | Pyrazolopyrimidinone compounds | 奥弗恩制药公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-111615388-B | Immunotherapeutic agent for cancer | 斯汀格瑞治疗股份有限公司 | 2023-11-14 | — | — | CN | disclosed |
| WO-2022204481-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS | Orphagen Pharmaceuticals, Inc. (US) | 2022-09-29 | — | — | WO | disclosed |