Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MITF | O75030 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL535878 | 1.00 | POLB (0.72) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL2434452 | 0.98 | POLB (0.70) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| Tert-Butylbenzene SCHEMBL27728888 | 0.89 | POLB (0.59) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL5468019 | 0.87 | POLB (0.57) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL30421484 | 0.87 | POLB (0.61) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL398161 | 0.87 | POLB (0.61) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL1558956 | 0.85 | POLB (0.68) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL1887873 | 0.85 | NR4A2 (0.67) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL29848366 | 0.85 | NR4A2 (0.67) | POLBNR4A2LMNAKMT2AALDH1A1 | |
| SCHEMBL21437406 | 0.84 | POLB (1.00) | POLBNR4A2LMNAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111295382-B | Bridged bicyclic compounds as farnesyl ester X receptor modulators | 百时美施贵宝公司 | 2024-02-02 | — | — | CN | claimed |
| EP-3704113-B1 | BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-10-11 | — | — | EP | claimed |
| US-20250236590-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | DEB INDUBHUSAN | 2025-07-24 | — | — | US | disclosed |
| US-20250090498-A1 | TREATMENT OF PRIMARY CTLA-4 CHECKPOINT RELATED IMMUNODEFICIENCIES | ADIENNE PHARMA & BIOTECH SA (CH) | 2025-03-20 | — | — | US | disclosed |
| WO-2024261641-A1 | TREATMENT OF PRIMARY CTLA-4 CHECKPOINT RELATED IMMUNODEFICIENCIES WITH 1H-INDOLE-3-CARBOXALDEHYDE OR 1-METHYLINDOLE-3-CARBOXYLIC ACID | ADIENNE PHARMA & BIOTECH SA (CH) | 2024-12-26 | — | — | WO | disclosed |
| EP-4419503-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) | 2024-08-28 | — | — | EP | disclosed |
| CN-118255685-A | Tricyclic compound, pharmaceutical composition and application thereof | 珂阑(上海)医药科技有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-110637015-B | Fanisole X receptor agonist and application thereof | 奥加诺沃公司 | 2024-04-02 | — | — | CN | disclosed |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| EP-3704113-B1 | BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2023067628-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN. OF SOC. ACT (ACT XXI OF 1860) (IN) | 2023-04-27 | — | — | WO | disclosed |
| US-11459315-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2022-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459315-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | TPMT, TET1, TET2 | POLB 371/4885NR4A2 3571/4885LMNA 3290/4885 |
| US-20250090498-A1 | TREATMENT OF PRIMARY CTLA-4 CHECKPOINT RELATED IMMUNODEFICIENCIES | CD274, PDCD1, ICOS | POLB 1018/4885NR4A2 2836/4885LMNA 4630/4885 |
| US-20250236590-A1 | A METHOD FOR THE PREPARATION OF INDOLE-3-CARBOXYLIC ACID DERIVATIVES | IDO1, INMT, IDO2 | POLB 4112/4885NR4A2 4512/4885LMNA 2920/4885 |
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | POLB 2458/4885NR4A2 2684/4885LMNA 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.