Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.81 |
| ▸ | CA9 | Q16790 | 6/20 | 0.81 |
| ▸ | CA2 | P00918 | 5/20 | 0.81 |
| ▸ | CA1 | P00915 | 3/20 | 0.81 |
| ▸ | CA7 | P43166 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | USP2 | O75604 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | BCHE | P06276 | 1/20 | 0.81 |
| ▸ | CA4 | P22748 | 1/20 | 0.81 |
| ▸ | CA6 | P23280 | 1/20 | 0.81 |
| ▸ | CA5A | P35218 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.81 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.81 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL3661332 | 1.00 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10380910 | 1.00 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL2731361 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27585928 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28969625 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27598742 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10400264 | 0.96 | CA12 (0.76) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10338383 | 0.93 | CA12 (0.71) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL29733582 | 0.93 | CA12 (0.76) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL29037506 | 0.90 | CA12 (0.92) | CA12CA9CA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2656 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355790-A1 | PROCESS FOR PREPARING POLYSACCHARIDE SULFATES, AND POLYSACCHARIDE SULFATE | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2024-04-24 | — | — | EP | claimed |
| EP-4181933-B1 | ANTIVIRAL PHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE SULPHATED POLYSACCHARIDE | MARINOMED BIOTECH AG (AT) | 2024-04-17 | — | — | EP | claimed |
| CN-117783318-A | HPLC method for separating and measuring related substances in polysaccharide polysulfonate | 重庆望业药物研究有限公司 | 2024-03-29 | — | — | CN | claimed |
| US-20240082391-A1 | ADJUVANT COMPRISING A GLYCOARCHAEOL AND AN IMMUNOSTIMULANT | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2024-03-14 | — | — | US | claimed |
| EP-2816964-B1 | HYDROGEL SYSTEM COMPRISING SPATIALLY SEPARATED BIOACTIVE POLYPEPTIDES | BEN GURION UNIV OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2023-12-27 | — | — | EP | claimed |
| EP-3999132-B1 | ECOBIOLOGICAL TREATMENT OF SIDE EFFECTS OF RADIOTHERAPY | BIONUCLEI (FR) | 2023-12-27 | — | — | EP | claimed |
| CN-117257831-A | Polysaccharide composition | 山西纳德西生物科技有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-117224493-A | Preparation method of ginseng polysaccharide sulfated nano-composite | 蓝科医美科学技术(吉林)有限公司 | 2023-12-15 | — | — | CN | claimed |
| EP-3518940-B1 | AQUEOUS COMPOSITION DERIVED FROM SEAWATER AND SEAWEED | YS LAB (FR) | 2023-11-22 | — | — | EP | claimed |
| EP-4274610-A1 | ADJUVANT COMPRISING A GLYCOARCHAEOL AND AN IMMUNOSTIMULANT | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2023-11-15 | — | — | EP | claimed |
| US-4637994-A | POROSITY, HARDNESS, GELS, IMMOBILIZATION, SULFATED COMPOUND, EPOXIDES, ACTIVATION, LIPOPROTEINS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-01-20 | — | — | US | claimed |
| EP-0175841-A2 | Method for the production of pertussis component vaccine and combined vaccine of pertussis antigen; diphtheria toxoid and tetanus toxoid | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute (JP) | 1986-04-02 | — | — | EP | claimed |
| EP-0170162-A2 | Method for the purification of leukocytosis-promoting factor haemagglutinin | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute (JP) | 1986-02-05 | — | — | EP | claimed |
| US-4563303-A | CHROMATOGRAPHY OF SUPERNATANT OF BORDETELLA CULTURE | JUDICIAL FOUNDATION THE CHEMOSERO-THERAPEUTIC RESEARCH INSTITUTE (JP) | 1986-01-07 | — | — | US | claimed |
| EP-0159003-A2 | Method for purification of filamentous hemagglutinin | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute (JP) | 1985-10-23 | — | — | EP | claimed |
| EP-0051354-B1 | ANTITHROMBOGENIC ARTICLES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1985-06-19 | — | — | EP | claimed |
| EP-0045282-B1 | ANTIHERPES LIPSTICK AND ITS USE IN TREATING LIPS AND OTHER FACE PARTS ATTACKED BY HERPES HOMINIS | CIBA-GEIGY AG (CH) | 1985-05-29 | — | — | EP | claimed |
| EP-0041449-B1 | APPLICATION OF AN OPHTHALMIC COMPOSITION CONTAINING A PLASMINOGEN ACTIVATOR TO CONTACT LENSES CLEANING | PIERRE FABRE S.A. (FR) | 1984-03-14 | — | — | EP | claimed |
| EP-0011322-B1 | ANTICOAGULANT AGENT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AKZO N.V. (NL) | 1982-05-05 | — | — | EP | claimed |
| EP-0041449-A1 | Application of an ophthalmic composition containing a plasminogen activator to contact lenses cleaning | PIERRE FABRE S.A. (FR) | 1981-12-09 | — | — | EP | claimed |