Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Saccharin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.81 |
| ▸ | CA9 | Q16790 | 6/20 | 0.81 |
| ▸ | CA2 | P00918 | 5/20 | 0.81 |
| ▸ | CA1 | P00915 | 3/20 | 0.81 |
| ▸ | CA7 | P43166 | 2/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | USP2 | O75604 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | BCHE | P06276 | 1/20 | 0.81 |
| ▸ | CA4 | P22748 | 1/20 | 0.81 |
| ▸ | CA6 | P23280 | 1/20 | 0.81 |
| ▸ | CA5A | P35218 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.81 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.81 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saccharin SCHEMBL299663 | 1.00 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10380910 | 1.00 | CA12 (0.81) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL2731361 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27585928 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL28969625 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL27598742 | 0.98 | CA12 (0.79) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10400264 | 0.96 | CA12 (0.76) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL10338383 | 0.93 | CA12 (0.71) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL29733582 | 0.93 | CA12 (0.76) | CA12CA9CA2CA1CA7 | |
| Saccharin SCHEMBL29037506 | 0.90 | CA12 (0.92) | CA12CA9CA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116063360-A | Disaccharide polysulfate for improving skin function, and preparation method and application thereof | 麦吉丽生物科技有限公司 | 2023-05-05 | — | — | CN | claimed |
| US-20210047366-A1 | ANDRIAS DAVIDIANUS CARTILAGE PREPARATION | UNIV TSINGHUA (CN) | 2021-02-18 | — | — | US | claimed |
| CN-112094360-A | Astragalus polysaccharide sulphuric acid modification equipment | 江苏南农高科动物药业有限公司 | 2020-12-18 | — | — | CN | claimed |
| EP-3166957-B1 | SULFATED-GLYCOLIPIDS AS ADJUVANTS FOR VACCINES | NAT RES COUNCIL CANADA (CA) | 2019-11-13 | — | — | EP | claimed |
| CN-110404106-A | A kind of polysaccharide dressing and its preparation method and application for wound repair | INST OCEANOLOGY CAS | 2019-11-05 | — | — | CN | claimed |
| CN-105037580-B | A kind of method that fucoxanthin and algal polysaccharide sulfate are comprehensively extracted from sargassum | 宁波大学 | 2017-07-18 | — | — | CN | claimed |
| CN-106645483-A | Method for quantitatively detecting sea cucumber polysaccharide | 大连工业大学 | 2017-05-10 | — | — | CN | claimed |
| EP-2667186-B1 | FINE STRUCTURE DETERMINATION METHOD OF ENOXAPARIN SODIUM BASED ON CAPILLARY ELECTROPHORESIS | Hangzhou jiuyuan gene engineering co ltd (CN) | 2015-10-14 | — | — | EP | claimed |
| CN-103666835-A | Special disinfecting detergent for infant feeding bottles | DAOHE BIOTECHNOLOGY CO LTD | 2014-03-26 | — | — | CN | claimed |
| CN-101011412-A | Usage of low-molecular-weight algal polysaccharide sulfate in preparation of medicament for treating hepatic disease | BEIJING CENTURY BIOCOM PHARM (CN) | 2007-08-08 | — | — | CN | claimed |
| EP-0640346-B1 | Uses of sulphated sugars against inflammation | BM RES AS (DK) | 2000-11-15 | — | — | EP | claimed |
| EP-0688327-B1 | ANALOGS FOR SPECIFIC OLIGOSACCHARIDE-PROTEIN INTERACTIONS AND USES THEREFOR | GLYCAN PHARM INC (US) | 1999-05-06 | — | — | EP | claimed |
| EP-0469010-B1 | COSMETIC COMPOSITION | BM RES AS (DK) | 1996-02-28 | — | — | EP | claimed |
| EP-0504645-B1 | Use of sulphated oligosaccharides for the treatment of arteriosclerotic diseases and for the prevention of restenosis | HOFFMANN LA ROCHE (CH) | 1995-10-18 | — | — | EP | claimed |
| EP-0394333-B1 | USES OF SULPHATED SUGARS | BUKH MEDITEC (DK) | 1995-03-15 | — | — | EP | claimed |
| CN-117460953-A | Cancer biomarkers | 爱丽卜塔有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-117297998-A | Anti-aging composition, anti-aging skin care product and preparation method thereof | 麦吉丽生物科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-1995034313-A1 | METHODS FOR TREATING CANCER AND OTHER CELL PROLIFERATIVE DISEASES | NEW YORK UNIVERSITY (US) | 1995-12-21 | — | — | WO | disclosed |
| EP-0084999-B1 | PROCESS FOR THE PREPARATION OF ORGANIC OLIGOSACCHARIDES, CORRESPONDING TO FRAGMENTS OF NATURAL MUCO-POLYSACCHARIDES, OLIGOSACCHARIDES OBTAINED AND THEIR BIOLOGICAL APPLICATIONS | D.R.O.P.I.C. (Société Civile) (FR) | 1988-04-13 | — | — | EP | disclosed |
| EP-0084999-A1 | Process for the preparation of organic oligosaccharides, corresponding to fragments of natural muco-polysaccharides, oligosaccharides obtained and their biological applications | D.R.O.P.I.C. (Société Civile) (FR) | 1983-08-03 | — | — | EP | disclosed |