Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | CDC7 | O00311 | 6/20 | 0.64 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289139 | 0.92 | KDM4E (0.86) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL288534 | 0.92 | KDM4E (0.86) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL290099 | 0.90 | KDM4E (0.81) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL288994 | 0.89 | KDM4E (0.80) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL289613 | 0.88 | KDM4E (0.78) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL290007 | 0.87 | KDM4E (0.76) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL290249 | 0.87 | KDM4E (0.76) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL289644 | 0.86 | KDM4E (0.74) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL299676 | 0.84 | KDM4E (0.72) | KDM4EALDH1A1GAACDC7DBF4 | |
| SCHEMBL289916 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1GAACDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107151243-B | 2-substituted-4-methyl-5- (4, 5-dihydrothiazole-2-yl) -1, 3-thiazole compounds, preparation method and biological activity evaluation thereof | 江苏海洋大学 | 2020-09-08 | — | — | CN | disclosed |
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |
| CN-1242994-C | Novel heterocyclic compound and medicinal use thereof | KYOTO PHARMA IND (JP) | 2006-02-22 | — | — | CN | disclosed |