Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389758 | 1.00 | TGFBR1 (0.36) | TGFBR1CYP2D6TGFBR2MAP3K20KDR | |
| SCHEMBL23391985 | 0.94 | TGFBR1 (0.37) | TGFBR1CYP2D6TGFBR2MAP3K20MAPK14 | |
| SCHEMBL23392260 | 0.94 | TGFBR1 (0.37) | TGFBR1CYP2D6TGFBR2MAP3K20MAPK14 | |
| SCHEMBL23391900 | 0.87 | TGFBR1 (0.38) | TGFBR1CYP2D6TGFBR2MAP3K20KDR | |
| SCHEMBL23391897 | 0.87 | TGFBR1 (0.38) | TGFBR1CYP2D6TGFBR2MAP3K20KDR | |
| SCHEMBL23392159 | 0.84 | IRAK4 (0.40) | TGFBR1CYP2D6TGFBR2MAP3K20MAPK14 | |
| SCHEMBL23392024 | 0.83 | IRAK4 (0.41) | TGFBR1CYP2D6TGFBR2MAP3K20KDR | |
| SCHEMBL22103184 | 0.82 | MET (0.41) | TGFBR1MAPK14PDGFRAMETTNIK | |
| SCHEMBL22074872 | 0.82 | MET (0.41) | TGFBR1MAPK14PDGFRAMETTNIK | |
| SCHEMBL23392175 | 0.79 | TGFBR1 (0.45) | TGFBR1KDRMAPK14PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061809-A1 | SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-09-28 | — | — | EP | disclosed |