Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 6/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130327 | 1.00 | CACNA1B (0.47) | CACNA1BCACNA1HPIK3CGSLC40A1KMT2A | |
| SCHEMBL29970032 | 0.97 | CACNA1B (0.51) | CACNA1BCACNA1HPIK3CGSLC40A1KMT2A | |
| SCHEMBL29969232 | 0.87 | SLC40A1 (0.44) | CACNA1BCACNA1HSLC40A1SMN1; SMN2PIK3CA | |
| SCHEMBL21513456 | 0.87 | SLC40A1 (0.44) | CACNA1BCACNA1HSLC40A1SMN1; SMN2PIK3CA | |
| SCHEMBL29968192 | 0.87 | ALDH1A1 (0.48) | CACNA1BCACNA1HKMT2AMAPTALDH1A1 | |
| SCHEMBL21513762 | 0.87 | ALDH1A1 (0.48) | CACNA1BCACNA1HKMT2AMAPTALDH1A1 | |
| SCHEMBL21512853 | 0.86 | CACNA1B (0.55) | CACNA1BCACNA1HKMT2AALDH1A1MEN1 | |
| SCHEMBL29968351 | 0.86 | CACNA1B (0.55) | CACNA1BCACNA1HKMT2AALDH1A1MEN1 | |
| SCHEMBL21513746 | 0.85 | CACNA1B (0.48) | CACNA1BCACNA1HALDH1A1SMN1; SMN2PIK3CA | |
| SCHEMBL29969263 | 0.85 | CACNA1B (0.48) | CACNA1BCACNA1HALDH1A1SMN1; SMN2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12187742-B2 | Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy | XRAD THERAPEUTICS, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| US-20220315606-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD HOLDING CAYMAN LIMITED (KY) | 2022-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220315606-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | ATM, CHEK2, CHEK1 | CACNA1B 4878/4885CACNA1H 4862/4885PIK3CG 1125/4885 |
| US-12187742-B2 | Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy | ATM, CHEK2, CHEK1 | CACNA1B 4878/4885CACNA1H 4862/4885PIK3CG 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.