Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.57 |
| ▸ | PDE4A | P27815 | 13/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.57 |
| ▸ | TNF | P01375 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987098 | 0.89 | TNF (0.67) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL7432712 | 0.89 | PDE4A (0.71) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL2992227 | 0.85 | TNF (0.67) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL7436772 | 0.84 | TNF (0.67) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL2992015 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL2996872 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DTNF | |
| SCHEMBL28453492 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4D | |
| SCHEMBL28456696 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4D | |
| SCHEMBL28462054 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4D | |
| SCHEMBL2997580 | 0.84 | PDE4B (0.80) | PDE4BPDE4CPDE4APDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | claimed |
| US-8466191-B2 | Pyrroline derivatives against cell releasing tumor necrosis factor, preparation methods and uses thereof | ZHANG HESHENG (CN) | 2013-06-18 | — | — | US | disclosed |
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | ZHANG HESHENG | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179189-A1 | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | TNF, IL1B, NOS1 | PDE4B 2498/4885PDE4C 2510/4885PDE4A 2306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.