Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27082391 | 1.00 | MEN1 (0.32) | MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL24409256 | 0.84 | RAB9A (0.32) | MEN1KMT2ACYP11B1CYP11B2 | |
| SCHEMBL29972943 | 0.79 | CYP11B1 (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL27082322 | 0.79 | CYP11B1 (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL27082404 | 0.77 | KDM4E (0.35) | KMT2A | |
| SCHEMBL29973045 | 0.77 | KDM4E (0.35) | KMT2A | |
| SCHEMBL30630824 | 0.74 | GCG (0.36) | — | |
| SCHEMBL24409267 | 0.74 | GCG (0.36) | — | |
| SCHEMBL24409184 | 0.73 | SLC34A1 (0.31) | — | |
| SCHEMBL28619768 | 0.71 | MEN1 (0.31) | MEN1KMT2ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117327078-A | Heterocyclic compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-117263945-A | Heterocyclic compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-113316578-B | Heterocyclic compound, pharmaceutical composition containing same, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116801882-A | Use and method of heterocyclic compounds for treating diseases associated with kinase resistant mutations | 四川科伦博泰生物医药股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| WO-2022199503-A1 | USE OF HETEROCYCLIC COMPOUND IN TREATING DISEASES RELATED TO KINASE DRUG-RESISTANT MUTATION AND METHOD THEREFOR | 四川科伦博泰生物医药股份有限公司 | 2022-09-29 | — | — | WO | disclosed |