Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BMP4 | P12644 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL361719 | 1.00 | KDM4E (0.54) | KDM4ERAB9ANPC1NCF1HTR3E | |
| SCHEMBL31410791 | 0.79 | FGFR1 (0.44) | KDM4EFGFR1 | |
| SCHEMBL29967853 | 0.73 | KDM4E (0.51) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL3594951 | 0.73 | KDM4E (0.51) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL3594952 | 0.71 | KDM4E (0.49) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL29648618 | 0.71 | KDM4E (0.49) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL363828 | 0.71 | KDM4E (1.00) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL11472894 | 0.68 | KDM4E (0.62) | KDM4ERAB9ANPC1HPGDHSD17B10 | |
| SCHEMBL2511897 | 0.68 | KDM4E (0.42) | KDM4ERAB9ANPC1NCF1HPGD | |
| SCHEMBL4788149 | 0.68 | KDM4E (0.46) | KDM4ERAB9AHPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307067-B1 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME LLC (US) | 2022-11-02 | — | — | EP | claimed |
| CN-116969954-B | Tricyclic fused heterocyclic compounds containing lactam and application thereof | 广东省农业科学院农业质量标准与监测技术研究所 | 2023-11-28 | — | — | CN | disclosed |
| CN-116969954-A | Tricyclic fused heterocyclic compounds containing lactam and application thereof | 广东省农业科学院农业质量标准与监测技术研究所 | 2023-10-31 | — | — | CN | disclosed |
| WO-2022250228-A1 | HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING SAME | 엘티소재주식회사 | 2022-12-01 | — | — | WO | disclosed |