Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.30 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.30 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.30 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29155747 | 0.80 | KMT2A (0.46) | SYKALDH1A1L3MBTL1KMT2A | |
| SCHEMBL19814334 | 0.76 | KMT2A (0.35) | FLT4SYKKDRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28331150 | 0.74 | KMT2A (0.34) | SYKALDH1A1LMNAL3MBTL1OPRM1 | |
| Hydrochloric Acid SCHEMBL19817403 | 0.74 | KMT2A (0.34) | SYKALDH1A1LMNAL3MBTL1OPRM1 | |
| SCHEMBL23850569 | 0.73 | FLT4 (0.34) | FLT4SYKKDRMAP4K4LMNA | |
| SCHEMBL29974013 | 0.73 | FLT4 (0.34) | FLT4SYKKDRMAP4K4LMNA | |
| SCHEMBL12002704 | 0.70 | MAP4K4 (0.37) | FLT4SYKMAP4K4ALDH1A1LMNA | |
| SCHEMBL30686563 | 0.70 | ALDH1A1 (0.32) | FLT4ALDH1A1 | |
| SCHEMBL23706250 | 0.69 | — | — | |
| SCHEMBL3679512 | 0.68 | NAPRT (0.42) | ALDH1A1LMNAL3MBTL1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124511-B | Tacrine derivatives, preparation method thereof and application of tacrine derivatives as CDK2/9 inhibitor | 中国人民解放军北部战区总医院 | 2023-09-26 | — | — | CN | disclosed |
| CN-115124511-A | Tacrine derivative, preparation method thereof and application of tacrine derivative as CDK2/9 inhibitor | 中国人民解放军北部战区总医院 | 2022-09-30 | — | — | CN | disclosed |