SCHEMBL29975464

SCHEMBL29975464

N#Cc1cc(O)ccc1C1CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 9/20 0.39
ESR1 P03372 6/20 0.39
AR P10275 3/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 2/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
CASP7 P55210 1/20 0.38
SLC22A12 Q96S37 2/20 0.38
CYP2C9 P11712 1/20 0.38
CA9 Q16790 2/20 0.38
MIF P14174 1/20 0.38
DYRK1A Q13627 1/20 0.38
CA12 O43570 1/20 0.37
CA2 P00918 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21590212 0.85 CYP1A2 (0.52) ESR2ESR1ARMAPTCYP2C9
SCHEMBL12326824 0.78 DRD4 (0.42) ARCHRNB2CHRNA4ALDH1A1ALOX15
SCHEMBL15769819 0.78 KDM4E (0.46) CHRNB2CHRNA4ALDH1A1LMNAMAPT
SCHEMBL16956827 0.78 SLC22A12 (0.33) CHRNB2CHRNA4ALDH1A1SLC22A12CYP2C9
SCHEMBL3652428 0.77 OPRK1 (0.44) ESR2ESR1ALDH1A1MAPK1LMNA
SCHEMBL16961015 0.76 CHRNA1 (0.37) CHRNB2CHRNA4ALDH1A1SLC22A12CYP2C9
SCHEMBL16958218 0.76 SLC22A12 (0.37) CHRNB2CHRNA4ALDH1A1SLC22A12CYP2C9
SCHEMBL15716003 0.76 AR (0.36) AR
SCHEMBL16954659 0.76 SLC22A12 (0.32) CHRNB2CHRNA4ALDH1A1SLC22A12CYP2C9
SCHEMBL15783462 0.74 KIF11 (0.38) ARALDH1A1MAPTALOX15MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090792-A1 AMIDE PRODRUGS AND USES THEREOF AUTOBAHN THERAPEUTICS, INC. (US) 2025-05-01 WO disclosed
EP-4329757-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2024-03-06 EP disclosed
CN-117561063-A Heterocyclic compounds and methods of use 安进公司 2024-02-13 CN disclosed
WO-2022232331-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2022-11-03 WO disclosed