Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28902108 | 1.00 | TLR8 (0.53) | TLR8CYP11B1CYP11B2CYP2D6ALDH1A1 | |
| SCHEMBL2144380 | 0.84 | ALDH1A1 (0.49) | CYP11B1CYP11B2CYP2D6ALDH1A1ATM | |
| SCHEMBL30842282 | 0.84 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL3207917 | 0.83 | TLR8 (0.57) | TLR8ALDH1A1MAPT | |
| Ammonia Solution, Strong SCHEMBL22775887 | 0.83 | CYP11B1 (0.52) | CYP11B1CYP11B2CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL3218795 | 0.78 | TLR8 (0.62) | TLR8LTA4H | |
| SCHEMBL3206611 | 0.77 | TLR8 (0.60) | TLR8 | |
| SCHEMBL28802664 | 0.76 | ALDH1A1 (0.49) | CYP2D6ALDH1A1ATMLTA4HAPP | |
| SCHEMBL30779218 | 0.76 | ALDH1A1 (0.49) | CYP2D6ALDH1A1ATMLTA4HAPP | |
| SCHEMBL3214978 | 0.74 | TP53 (0.47) | TLR8ALDH1A1CYP1A2HSP90AB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | LUPIN LIMITED (IN) | 2022-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459330-B2 | Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | TLR8 4654/4885CYP11B1 506/4885CYP11B2 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.