Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499900 | 1.00 | ALDH1A1 (0.38) | ALDH1A1ALDH1A3TDP1HSD17B10CYP2A6 | |
| SCHEMBL1467753 | 0.88 | CYP2A6 (0.36) | ALDH1A1ALDH1A3TDP1HSD17B10CYP2A6 | |
| SCHEMBL19211659 | 0.82 | ALDH1A1 (0.37) | ALDH1A1TDP1HSD17B10CYP2A6P4HB | |
| SCHEMBL28698510 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3TDP1HSD17B10CYP2A6 | |
| SCHEMBL29820394 | 0.82 | ALDH1A1 (0.37) | ALDH1A1TDP1HSD17B10CYP2A6P4HB | |
| SCHEMBL31584071 | 0.82 | ALDH1A1 (0.47) | ALDH1A1ALDH1A3TDP1HSD17B10CYP2A6 | |
| SCHEMBL28476218 | 0.81 | ALDH1A1 (0.37) | ALDH1A1ALDH1A3TDP1HSD17B10CYP2A6 | |
| SCHEMBL21358544 | 0.81 | LPL (0.35) | ALDH1A1ALDH1A3TDP1HSD17B10P4HB | |
| SCHEMBL24107274 | 0.80 | LPL (0.38) | ALDH1A1TDP1HSD17B10CYP2A6P4HB | |
| SCHEMBL31533278 | 0.80 | LPL (0.38) | ALDH1A1TDP1HSD17B10CYP2A6P4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2023172957-A1 | THAIZOLE-PYRIMDIINE CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2023-09-14 | — | — | WO | disclosed |
| WO-2022235945-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | BIOGEN MA INC. (US) | 2022-11-10 | — | — | WO | disclosed |