Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.50 |
| ▸ | AXL | P30530 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 5/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | TDO2 | P48775 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28799165 | 1.00 | NOS1 (0.50) | NOS1AXLTRPA1PTPN6METAP2 | |
| SCHEMBL25367669 | 0.80 | AXL (0.51) | NOS1AXLTRPA1METAP2IDO1 | |
| SCHEMBL18456308 | 0.79 | AXL (0.50) | NOS1AXLTRPA1METAP2IDO1 | |
| SCHEMBL5404571 | 0.79 | AXL (0.50) | NOS1AXLTRPA1METAP2IDO1 | |
| SCHEMBL767674 | 0.76 | NOS1 (0.55) | NOS1AXLTRPA1PTPN6METAP2 | |
| SCHEMBL29383280 | 0.75 | AXL (0.59) | NOS1AXLTRPA1PTPN6METAP2 | |
| SCHEMBL19617855 | 0.75 | AXL (0.59) | NOS1AXLTRPA1PTPN6METAP2 | |
| SCHEMBL2427200 | 0.75 | AXL (0.46) | AXLTRPA1METAP2CDK2CCNA1 | |
| SCHEMBL5417197 | 0.75 | METAP2 (0.47) | AXLTRPA1METAP2IDO1FLT3 | |
| SCHEMBL12293667 | 0.75 | AXL (0.46) | NOS1AXLTRPA1METAP2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212819-A1 | INDAZOLE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |