Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | TDO2 | P48775 | 4/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478370 | 1.00 | PLK4 (0.41) | PLK4PAK4EPAS1AKT1TDO2 | |
| SCHEMBL23478324 | 0.90 | HDAC3 (0.42) | EPAS1TDO2IDO1ADRA2AADRA2C | |
| SCHEMBL29981228 | 0.90 | IDO1 (0.43) | EPAS1AKT1TDO2IDO1KDM4E | |
| SCHEMBL23478340 | 0.90 | IDO1 (0.43) | EPAS1AKT1TDO2IDO1KDM4E | |
| SCHEMBL23461416 | 0.87 | KDM4E (0.40) | PLK4PAK4EPAS1TDO2IDO1 | |
| SCHEMBL23478343 | 0.85 | IDO1 (0.39) | PLK4PAK4EPAS1TDO2IDO1 | |
| SCHEMBL23478156 | 0.79 | LMNA (0.41) | EPAS1AKT1TDO2IDO1RPS6KB1 | |
| SCHEMBL23478799 | 0.79 | EPAS1 (0.36) | EPAS1TDO2IDO1 | |
| SCHEMBL23478125 | 0.76 | EPAS1 (0.39) | EPAS1AKT1AURKA | |
| SCHEMBL29780217 | 0.76 | EPAS1 (0.39) | EPAS1AKT1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069212-A1 | INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |