Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.43 |
| ▸ | TDO2 | P48775 | 5/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | ARNT | P27540 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23478340 | 1.00 | IDO1 (0.43) | IDO1TDO2P2RX7ALDH1A1SMN1; SMN2 | |
| SCHEMBL29980738 | 0.90 | PLK4 (0.41) | IDO1TDO2EPAS1KDM4EAKT1 | |
| SCHEMBL23478370 | 0.90 | PLK4 (0.41) | IDO1TDO2EPAS1KDM4EAKT1 | |
| SCHEMBL23478324 | 0.88 | HDAC3 (0.42) | IDO1TDO2P2RX7EPAS1ARNT | |
| SCHEMBL23478343 | 0.83 | IDO1 (0.39) | IDO1TDO2EPAS1 | |
| SCHEMBL23478799 | 0.81 | EPAS1 (0.36) | IDO1TDO2EPAS1 | |
| SCHEMBL23461416 | 0.81 | KDM4E (0.40) | IDO1TDO2ALDH1A1EPAS1KDM4E | |
| SCHEMBL23478156 | 0.78 | LMNA (0.41) | IDO1TDO2EPAS1AKT1 | |
| SCHEMBL23478762 | 0.74 | EPAS1 (0.41) | EPAS1 | |
| SCHEMBL29780231 | 0.74 | EPAS1 (0.41) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069212-A1 | INHIBITORS OF HIF-2ALPHA | Arcus Biosciences, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |