⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30470204 | 0.71 | MAPT (0.50) | — | |
| SCHEMBL24367664 | 0.71 | MAPT (0.50) | — | |
| SCHEMBL24718998 | 0.68 | CYP3A4 (0.46) | — | |
| SCHEMBL29672433 | 0.62 | KDM1A (0.47) | — | |
| SCHEMBL29672436 | 0.62 | KDM1A (0.47) | — | |
| SCHEMBL15341900 | 0.61 | WDR5 (0.49) | — | |
| SCHEMBL31556406 | 0.61 | FAAH (0.39) | — | |
| SCHEMBL24367658 | 0.59 | RECQL (0.42) | — | |
| SCHEMBL22780705 | 0.59 | — | — | |
| SCHEMBL20896958 | 0.59 | HTR2A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279219-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-08-22 | — | — | US | disclosed |
| US-20230113778-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2023-04-13 | — | — | US | disclosed |
| US-11492350-B2 | Compounds and methods of use | TANGO THERAPEUTICS, INC. (US) | 2022-11-08 | — | — | US | disclosed |