Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.71 |
| ▸ | HTR1D | P28221 | 8/20 | 0.71 |
| ▸ | HTR1B | P28222 | 7/20 | 0.71 |
| ▸ | HTR2C | P28335 | 12/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | HTR2B | P41595 | 4/20 | 0.62 |
| ▸ | HTR1E | P28566 | 3/20 | 0.62 |
| ▸ | HTR1F | P30939 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 3/20 | 0.62 |
| ▸ | HTR3A | P46098 | 3/20 | 0.62 |
| ▸ | HTR5A | P47898 | 3/20 | 0.62 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.58 |
| ▸ | HTR3B | O95264 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121941 | 0.85 | HTR1A (0.76) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL31574201 | 0.83 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL22612481 | 0.83 | HTR1A (1.00) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL10753877 | 0.82 | HTR1A (0.67) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL15701887 | 0.82 | HTR1A (0.76) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL1750326 | 0.82 | HTR1A (0.76) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL13653014 | 0.82 | HTR1A (0.81) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL2990479 | 0.81 | HTR1A (0.63) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL10570559 | 0.81 | HTR1A (0.71) | HTR1AHTR1DHTR1BHTR2CHTR2A | |
| SCHEMBL13647702 | 0.80 | HTR1A (0.72) | HTR1AHTR1DHTR1BHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786156-B2 | Synthesis methods and intermediates for the manufacture of Rizatriptan | RATIOPHARM GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| EP-1751104-B1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2010-03-24 | — | — | EP | disclosed |
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | RATIOPHARM GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| EP-1751104-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | ratiopharm GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005075422-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | HTR7, HRH4, CA7 | HTR1A 31/4885HTR1D 48/4885HTR1B 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.