Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | HTR2B | P41595 | 6/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 6/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 1.00 |
| ▸ | DRD2 | P14416 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 6/20 | 1.00 |
| ▸ | DRD3 | P35462 | 6/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 5/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 5/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | HTR2C | P28335 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | DRD1 | P21728 | 4/20 | 1.00 |
| ▸ | MC3R | P41968 | 4/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melitracen SCHEMBL48975 | 1.00 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL121493 | 0.98 | HRH1 (0.97) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL29399425 | 0.98 | HRH1 (0.97) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL2473296 | 0.98 | HRH1 (0.97) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL1650139 | 0.97 | HRH1 (0.94) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL29195738 | 0.97 | HRH1 (0.94) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Litracen SCHEMBL2109078 | 0.77 | SLC6A2 (0.62) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL38527 | 0.76 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL29520569 | 0.76 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL7654526 | 0.76 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025262247-A1 | TREATMENT OF HEADACHE DISORDERS AND/OR PSYCHIATRIC SYMPTOMS USING ANTI-CGRP ANTIBODIES, AND COMPOSITIONS AND METHODS RELATED THERETO | H. LUNDBECK A/S (DK) | 2025-12-26 | — | — | WO | disclosed |
| WO-2024197124-A9 | ARGININE VASOPRESSIN RECEPTOR (AVPR) ANTAGONISTS AND METHODS OF USING THEREOF | UNIVERSITY OF MIAMI (US) | 2024-12-19 | — | — | WO | disclosed |
| WO-2024197124-A2 | ARGININE VASOPRESSIN RECEPTOR (AVPR) ANTAGONISTS AND METHODS OF USING THEREOF | UNIVERSITY OF MIAMI (US) | 2024-09-26 | — | — | WO | disclosed |
| CN-112300119-B | Metliquxin and flupentixol eutectic and preparation method thereof | 苏州恩华生物医药科技有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-115417753-A | Synthetic method of melitracen and intermediate thereof | 重庆西南制药二厂有限责任公司 | 2022-12-02 | — | — | CN | disclosed |
| WO-2022198003-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 | VANDERBILT UNIVERSITY (US) | 2022-09-22 | — | — | WO | disclosed |