Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Melitracen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 8/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.97 |
| ▸ | KCNH2 known ✓ | Q12809 | 7/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 6/20 | 0.97 |
| ▸ | CHRM2 known ✓ | P08172 | 6/20 | 0.97 |
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.97 |
| ▸ | DRD2 known ✓ | P14416 | 6/20 | 0.97 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 6/20 | 0.97 |
| ▸ | ADRA2C known ✓ | P18825 | 5/20 | 0.97 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.97 |
| ▸ | HTR1A known ✓ | P08908 | 5/20 | 0.97 |
| ▸ | ADRA2A known ✓ | P08913 | 5/20 | 0.97 |
| ▸ | ADRA2B known ✓ | P18089 | 4/20 | 0.97 |
| ▸ | DRD1 known ✓ | P21728 | 4/20 | 0.97 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 3/20 | 0.97 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melitracen SCHEMBL2473296 | 1.00 | HRH1 (0.97) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL121493 | 1.00 | HRH1 (0.97) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL29195738 | 0.98 | HRH1 (0.94) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL48975 | 0.98 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL29984590 | 0.98 | HRH1 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Melitracen SCHEMBL1650139 | 0.95 | HRH1 (0.94) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL41376 | 0.77 | LMNA (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL4964925 | 0.77 | LMNA (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Cyclobenzaprine SCHEMBL29350662 | 0.77 | LMNA (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 | |
| Amitriptyline SCHEMBL14937172 | 0.75 | SLC6A2 (1.00) | HRH1SLC6A2KCNH2HTR2BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115417753-A | Synthetic method of melitracen and intermediate thereof | 重庆西南制药二厂有限责任公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-113105335-B | Synthetic method of stable deuterium-labeled melitracen hydrochloride | 梯尔希（南京）药物研发有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114057586-A | Melletoxin hydrochloride crystal form A and preparation method thereof | 江苏恩华药业股份有限公司 | 2022-02-18 | — | — | CN | disclosed |