Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.62 |
| ▸ | HTR1A | P08908 | 4/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.62 |
| ▸ | HTR2C | P28335 | 4/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HTR2B | P41595 | 4/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.62 |
| ▸ | DRD1 | P21728 | 3/20 | 0.62 |
| ▸ | MC3R | P41968 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL28960098 | 0.79 | SLC6A2 (0.57) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Dimethylamine SCHEMBL28899930 | 0.78 | SLC6A2 (0.55) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Melitracen SCHEMBL29984590 | 0.77 | HRH1 (1.00) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Melitracen SCHEMBL48975 | 0.77 | HRH1 (1.00) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| SCHEMBL2240126 | 0.76 | LMNA (1.00) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| SCHEMBL29763692 | 0.76 | LMNA (1.00) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Melitracen SCHEMBL121493 | 0.75 | HRH1 (0.97) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Melitracen SCHEMBL2473296 | 0.75 | HRH1 (0.97) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Melitracen SCHEMBL29399425 | 0.75 | HRH1 (0.97) | SLC6A2SLC6A4HTR2ACHRM2HTR1A | |
| Nortriptyline SCHEMBL34527 | 0.75 | SLC6A2 (1.00) | SLC6A2SLC6A4HTR2ACHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240307393-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | NATIONAL CANCER CENTER (KR) | 2024-09-19 | — | — | US | claimed |
| EP-4368183-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | National Cancer Center (KR) | 2024-05-15 | — | — | EP | claimed |
| CN-117597126-A | Pharmaceutical composition for preventing or treating cancer comprising CDK4/6 inhibitor and tricyclic antidepressant | 国立癌症中心 | 2024-02-23 | — | — | CN | claimed |
| WO-2023282544-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | 국립암센터 | 2023-01-12 | — | — | WO | claimed |
| CN-105663062-B | A kind of flupentixol and melitracen pharmaceutical composition and preparation method thereof | 南京卓康医药科技有限公司 | 2019-01-29 | — | — | CN | claimed |
| CN-108362792-A | A kind of detection method of flupentixol and melitracen compound medicine impurity, new recognizable impurity and safer compound medicine | 成都倍特药业有限公司 | 2018-08-03 | — | — | CN | claimed |
| US-9016221-B2 | Surface topographies for non-toxic bioadhesion control | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-04-28 | — | — | US | claimed |
| US-20100226943-A1 | SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL | UNIVERSITY OF FLORIDA (US) | 2010-09-09 | — | — | US | claimed |
| CN-101330905-A | Freeze-drying process and products obtained thereby | SCIDOSE LLC (US) | 2008-12-24 | — | — | CN | claimed |
| EP-1954244-A1 | LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY | Scidose, Llc (US) | 2008-08-13 | — | — | EP | claimed |
| WO-2007061529-A1 | LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY | SCIDOSE LLC. (US) | 2007-05-31 | — | — | WO | claimed |
| US-20070116729-A1 | Lyophilization process and products obtained thereby | SCIDOSE LLC | 2007-05-24 | — | — | US | claimed |
| US-20240307393-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | NATIONAL CANCER CENTER (KR) | 2024-09-19 | — | — | US | disclosed |
| EP-4368183-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | National Cancer Center (KR) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023282544-A1 | PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT, COMPRISING CDK4/6 INHIBITOR AND TRICYCLIC ANTIDEPRESSANT | 국립암센터 | 2023-01-12 | — | — | WO | disclosed |
| US-20220047505-A1 | Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration | STI PHARMA, LLC (US) | 2022-02-17 | — | — | US | disclosed |
| US-6261537-B1 | TARGETS AND ULTRASOUND DIAGNOSIS OF ACTIVE MATERIALS, AQUEOUS CARRIER LIQUIDS, CARRIERS AND FILM FORMING SURFACTANT PHOSPHATIDES | NYCOMED IMAGING AS (NO) | 2001-07-17 | — | — | US | disclosed |
| EP-0371598-B1 | ANTIDOTES | ROUSSEL-UCLAF (FR) | 1992-06-03 | — | — | EP | disclosed |
| US-5023073-A | Method of combating flupropadine poisoning using phenothiazines | BURROUGHS WELLCOME CO. (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0371598-A1 | Antidotes | ROUSSEL-UCLAF (FR) | 1990-06-06 | — | — | EP | disclosed |