Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10109755 | 0.86 | ADORA2A (0.40) | SLC6A2HDAC8CRHR1 | |
| SCHEMBL17448068 | 0.79 | KLKB1 (0.37) | TLR7TLR8PDE10AFFAR1IRAK4 | |
| SCHEMBL31429234 | 0.79 | PDE10A (0.40) | PDE10ASLC6A2HDAC8CRHR1IRAK4 | |
| SCHEMBL31219820 | 0.78 | IRAK4 (0.36) | PDE10AFFAR1IRAK4 | |
| SCHEMBL26983072 | 0.78 | HDAC8 (0.38) | PDE10AFFAR1HDAC8IRAK4 | |
| SCHEMBL11604153 | 0.76 | HDAC8 (0.38) | SLC6A2HDAC8CRHR1 | |
| SCHEMBL5764690 | 0.76 | SLC6A2 (0.43) | TLR7TLR8SLC6A2HDAC8 | |
| SCHEMBL17453073 | 0.75 | NPC1 (0.34) | PDE10AFFAR1IRAK4 | |
| SCHEMBL28166543 | 0.75 | GABRP (0.37) | SLC6A2HDAC8CRHR1IRAK4 | |
| SCHEMBL29110339 | 0.74 | NPC1 (0.42) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022206730-A1 | PYRIMIDOPYRAZINE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-10-06 | — | — | WO | disclosed |