Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667405 | 1.00 | GRM5 (0.38) | GRM5CSF1RSLC6A3FGFR1FGFR4 | |
| SCHEMBL29987630 | 0.96 | GRM5 (0.38) | GRM5CSF1RSLC6A3FGFR1FGFR4 | |
| SCHEMBL24667654 | 0.96 | GRM5 (0.38) | GRM5CSF1RSLC6A3FGFR1FGFR4 | |
| Bicarbonate SCHEMBL27089504 | 0.93 | GRM5 (0.35) | GRM5CSF1RSLC6A3FGFR1FGFR4 | |
| Bicarbonate SCHEMBL27089503 | 0.92 | GRM5 (0.37) | GRM5CSF1RSLC6A3FGFR1FGFR4 | |
| SCHEMBL29165247 | 0.90 | GRM5 (0.43) | GRM5CSF1RPIK3CGCSNK1A1CSNK1D | |
| SCHEMBL24667346 | 0.86 | GRM5 (0.42) | GRM5SLC6A3PDE10AHRH3PIK3CG | |
| SCHEMBL24667632 | 0.86 | GRM5 (0.42) | GRM5SLC6A3PDE10A | |
| SCHEMBL29987375 | 0.86 | GRM5 (0.42) | GRM5SLC6A3PDE10AHRH3PIK3CG | |
| SCHEMBL29987068 | 0.86 | GRM5 (0.42) | GRM5SLC6A3PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |