Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KHK | P50053 | 1/20 | 0.44 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10087543 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL3607648 | 0.88 | KDM4E (0.44) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL8200210 | 0.88 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL589590 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL10783166 | 0.82 | KDM4E (0.44) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL11117158 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL11000333 | 0.82 | KDM4E (0.40) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL10780291 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL391115 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAAKHKUSP8 | |
| SCHEMBL2383543 | 0.81 | KDM4E (0.48) | ALDH1A1KDM4EGAAKHKUSP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |