Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24667588 | 1.00 | NPC1 (0.44) | NPC1PKMRAB9AMETAP1SLC11A2 | |
| SCHEMBL24667346 | 0.85 | GRM5 (0.42) | NPC1PKMRAB9APRMT5WDR77 | |
| SCHEMBL29987375 | 0.85 | GRM5 (0.42) | NPC1PKMRAB9APRMT5WDR77 | |
| SCHEMBL29987869 | 0.82 | PIK3CG (0.36) | NPC1PKMRAB9AHTR2CPDE10A | |
| SCHEMBL24667584 | 0.82 | PIK3CG (0.36) | NPC1PKMRAB9AHTR2CPDE10A | |
| SCHEMBL24667367 | 0.82 | CRBN (0.38) | ADAM17PRMT5WDR77 | |
| SCHEMBL29987001 | 0.82 | CRBN (0.38) | ADAM17PRMT5WDR77 | |
| SCHEMBL24667447 | 0.80 | HTR2C (0.35) | HTR2CPRMT5WDR77PDE10A | |
| SCHEMBL24667650 | 0.80 | PIK3CG (0.39) | HTR2CPRMT5WDR77 | |
| SCHEMBL24667652 | 0.80 | NR1H4 (0.37) | HTR2AHTR2CHTR2BPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320114-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-117412960-A | Isoindolinone compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022216947-A1 | ISOINDOLINONE COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2022-10-13 | — | — | WO | disclosed |