Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27816853 | 1.00 | KDM4E (0.36) | KDM4EALDH1A1KAT2BCD38HTT | |
| SCHEMBL14270186 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1KAT2B | |
| SCHEMBL19342476 | 0.78 | KDM4E (0.39) | KDM4EALDH1A1KAT2B | |
| SCHEMBL15409549 | 0.76 | ALDH1A1 (0.40) | KDM4EALDH1A1KAT2B | |
| SCHEMBL30228095 | 0.75 | CYP11B1 (0.41) | KDM4EALDH1A1KAT2B | |
| SCHEMBL25623827 | 0.75 | CYP11B1 (0.41) | KDM4EALDH1A1KAT2B | |
| SCHEMBL14354462 | 0.75 | BACE1 (0.43) | KDM4EALDH1A1KAT2BHTTMAP4K4 | |
| SCHEMBL28051170 | 0.73 | CD38 (0.36) | KDM4ECD38HTTHSD17B10TRPC5 | |
| SCHEMBL28770884 | 0.73 | IDO1 (0.46) | KDM4EALDH1A1KAT2B | |
| SCHEMBL15426712 | 0.72 | ALDH1A1 (0.37) | KDM4EALDH1A1KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638917-B | Heterocyclic compounds as kinase inhibitors, compositions comprising the same, and methods of use thereof | 捷思英达控股有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-111032656-B | Heterocyclic compound kinase inhibitor and pharmaceutical composition and application thereof | 捷思英达医药技术（上海）有限公司 | 2022-12-02 | — | — | CN | disclosed |