Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.63 |
| ▸ | FLT3 | P36888 | 18/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.63 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.63 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.63 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.63 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.63 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.63 |
| ▸ | ULK1 | O75385 | 2/20 | 0.54 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27087858 | 1.00 | CHEK1 (0.63) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL30800585 | 0.89 | CHEK1 (0.61) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL27087791 | 0.89 | CHEK1 (0.61) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL27087847 | 0.88 | CHEK1 (0.62) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL29989342 | 0.88 | CHEK1 (0.62) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL27403132 | 0.87 | CHEK1 (0.58) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL27403129 | 0.86 | CHEK1 (0.58) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL29989851 | 0.84 | ULK1 (0.73) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL27087849 | 0.84 | ULK1 (0.73) | CHEK1FLT3KITAURKARPS6KA5 | |
| SCHEMBL23764811 | 0.83 | PTK2 (0.55) | CHEK1FLT3KITAURKARPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320121-A2 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS ULK1/2 INHIBITORS AND THEIR USE THEREOF | LifeArc (GB) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214869-A2 | ULK1/2 INHIBITORS AND THEIR USE THEREOF | LIFEARC (GB) | 2022-10-13 | — | — | WO | disclosed |