Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28638549 | 1.00 | SYK (0.53) | SYKENPP2ERBB2EGFRERBB3 | |
| SCHEMBL29568574 | 0.82 | SYK (0.58) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL21340419 | 0.82 | SYK (0.58) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL29952431 | 0.80 | ENPP2 (0.66) | ENPP2MRGPRX4HTTMAPTHPGD | |
| SCHEMBL8453 | 0.80 | ENPP2 (0.66) | ENPP2MRGPRX4HTTMAPTHPGD | |
| SCHEMBL29989288 | 0.78 | SYK (0.57) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL17385133 | 0.78 | SYK (0.57) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL2760112 | 0.78 | SYK (0.59) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL29638125 | 0.78 | SYK (0.78) | SYKERBB2EGFRERBB3ERBB4 | |
| SCHEMBL159323 | 0.78 | SYK (0.78) | SYKERBB2EGFRERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493439-B | Substituted acrylamide derivative, composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2022-10-14 | — | — | CN | disclosed |