Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.62 |
| ▸ | GPR183 | P32249 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21225348 | 1.00 | HRH4 (0.62) | HRH4GPR183HRH3DRD2DRD3 | |
| SCHEMBL21225350 | 1.00 | HRH4 (0.62) | HRH4GPR183HRH3DRD2DRD3 | |
| SCHEMBL4329672 | 0.90 | HRH4 (0.65) | HRH4GPR183HRH3HRH1MEN1 | |
| SCHEMBL21225412 | 0.90 | HRH4 (0.65) | HRH4GPR183HRH3HRH1MEN1 | |
| SCHEMBL29990773 | 0.90 | HRH4 (0.65) | HRH4GPR183HRH3HRH1MEN1 | |
| Hydrochloric Acid SCHEMBL4325731 | 0.89 | HRH4 (0.64) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL21225525 | 0.85 | HRH4 (0.46) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL29990849 | 0.85 | HRH4 (0.46) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL21225528 | 0.85 | HRH4 (0.46) | HRH4HRH3HRH1MEN1RAB9A | |
| SCHEMBL1308032 | 0.82 | HRH4 (0.62) | HRH4GPR183HRH3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018033-B2 | Inhibitors of protein arginine deiminases | FORWARD THERAPEUTICS, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-11453676-B2 | Inhibitors of protein arginine deiminases | FORWARD THERAPEUTICS, INC. (US) | 2022-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11453676-B2 | Inhibitors of protein arginine deiminases | PADI2, PADI1, PADI4 | HRH4 2617/4885GPR183 3673/4885HRH3 1772/4885 |
| US-12018033-B2 | Inhibitors of protein arginine deiminases | PADI2, PADI1, PADI4 | HRH4 2369/4885GPR183 3713/4885HRH3 1604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.