Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15058202 | 1.00 | POLB (0.60) | POLBCHRM2LMNAALDH1A1PKM | |
| SCHEMBL21800486 | 0.87 | CHRM2 (0.59) | POLBCHRM2LMNAALDH1A1PKM | |
| SCHEMBL9763711 | 0.85 | PKM (0.74) | POLBLMNAALDH1A1PKMMAPK1 | |
| SCHEMBL22702046 | 0.84 | POLB (0.56) | POLBCHRM2ALDH1A1PKMMAPK1 | |
| Hydrochloric Acid SCHEMBL1596692 | 0.84 | PKM (0.72) | POLBLMNAALDH1A1PKMMAPK1 | |
| SCHEMBL6640482 | 0.82 | PKM (0.66) | POLBALDH1A1PKMMAPK1MEN1 | |
| SCHEMBL22702163 | 0.82 | PKM (0.66) | POLBLMNAALDH1A1PKMMAPK1 | |
| SCHEMBL29457007 | 0.82 | PKM (0.66) | POLBALDH1A1PKMMAPK1MEN1 | |
| SCHEMBL29944134 | 0.81 | ALDH1A1 (0.67) | POLBALDH1A1PKMMAPK1MEN1 | |
| SCHEMBL28324495 | 0.81 | ALDH1A1 (0.67) | POLBALDH1A1PKMMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117377668-A | Inhalant formulations of PGDH inhibitors and methods of use thereof | 迈欧伏特治疗公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-115335043-A | PGDH inhibitors and methods of making and using | 迈欧伏特治疗公司 | 2022-11-11 | — | — | CN | disclosed |