Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21063161 | 1.00 | ADORA2A (0.44) | ADORA2AADORA1TLR8KDM4EALDH1A1 | |
| SCHEMBL29995906 | 0.95 | ADORA2A (0.41) | ADORA2AADORA1TLR8KDM4EALDH1A1 | |
| SCHEMBL21062964 | 0.95 | ADORA2A (0.41) | ADORA2AADORA1TLR8KDM4EALDH1A1 | |
| SCHEMBL21063321 | 0.89 | ADORA1 (0.43) | ADORA2AADORA1TLR8PDE10AADORA3 | |
| SCHEMBL21063320 | 0.85 | ADORA2A (0.39) | ADORA2AADORA1TLR8KDM4EALDH1A1 | |
| SCHEMBL29996147 | 0.84 | ADORA2A (0.36) | ADORA2AADORA1ADORA2BAKR1A1AKR1B1 | |
| SCHEMBL29995953 | 0.84 | ALDH1A1 (0.41) | ADORA2AADORA1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL21063335 | 0.84 | ADORA2A (0.36) | ADORA2AADORA1ADORA2BAKR1A1AKR1B1 | |
| SCHEMBL21062956 | 0.84 | ALDH1A1 (0.41) | ADORA2AADORA1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL21063077 | 0.84 | BACE1 (0.45) | ADORA2AADORA1KDM4EALDH1A1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11498923-B2 | Substituted imidazo[1,2-c]quinazolines as A2A antagonists | MERCK SHARP & DOHME LLC (US) | 2022-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11498923-B2 | Substituted imidazo[1,2-c]quinazolines as A2A antagonists | ADORA2A, ADORA3, ADORA1 | ADORA2A 1/4885ADORA1 3/4885TLR8 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.