Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383944 | 0.83 | CYP1A2 (0.54) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL3420052 | 0.81 | GAA (0.49) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL6226310 | 0.80 | CYP1A2 (0.53) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL14697332 | 0.78 | GAA (0.61) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL3075342 | 0.77 | PLAU (0.50) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL1129046 | 0.75 | CYP2D6 (0.56) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL3072294 | 0.75 | NCEH1 (0.49) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL3070065 | 0.75 | ALDH1A1 (0.55) | ALDH1A1LMNAGAABCHEMAPT | |
| SCHEMBL28020779 | 0.75 | CYP1A2 (0.51) | CYP2D6CYP2C19CYP1A2CYP2C9TSHR | |
| SCHEMBL22281955 | 0.73 | ALDH1A1 (0.50) | CYP2C9ALDH1A1GAABCHEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427451-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BioLab Corporation (JP) | 2012-03-14 | — | — | EP | disclosed |
| EP-2303887-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | Prism Biolab Corporation (JP) | 2011-04-06 | — | — | EP | disclosed |